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HIGH RANKING STUDIES

• Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

• Consumption of water containing hydrogen could improve vascular endothelial function

• Effects of hydrogen-rich water on aging periodontal tissues in rats

• Effects of hydrogen-rich water on depressive-like behavior in mice

• Effect of Hydrogen-Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B

• Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

• Hyperbaric hydrogen therapy: a possible treatment for cancer

• Molecular hydrogen regulates gene expression by modifying the free radical chain reaction

• Molecular hydrogen stimulates the gene expression  to enhance fatty acid metabolism

• Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice

• Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial 

• The hydrogen highway to reperfusion therapy

• Hydrogen-rich water improves neurological functional recovery

MOLECULAR HYDROGEN

• Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles

• Comprehensive Review Study on the Clinical Effects of Hydrogen

• Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications

• Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases

• Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

• Molecular hydrogen: a therapeutic antioxidant and beyond

• The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance

• Recent Advances in Studies of Molecular Hydrogen against Sepsis (2019)

• Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women (2018)

• Hydrogen-Rich Saline as an Innovative Therapy for Cataract

• Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch (2020)

• Molecular hydrogen alleviates motor deficits and muscle degeneration (2017)

ELECTRICLY REDUCED WATER

• Hydrogen rich water in oral pathology (2018)

• The Efficacy and Tolerability of Electrolyzed Oxidized Water in Treating Mild to Moderate Acne

• Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury (2019)

• Hydrogen water alleviates obliterative airway disease (2020)

• The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome (2020)

• Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression (2020)

• Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver (2019)

• Effects of Electrolyzed Reduced Water (ERW) on NF-κB/iNOS Pathway in U937 Cell Line under Altered Redox State

• Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study

ATHLETES

• Increased ATP production: Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration

• Increased ATP production: Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury

• Increased ATP production: Stimulation of human damaged sperm motility with hydrogen molecule

• Increased Metabolism: Molecular hydrogen stimulates the gene expression of transcriptional co-activator PGC-1α to enhance fatty acid metabolism

• Prevents Muscle fatigue/reduces lactic acid: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes  

• Selective antioxidant: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

• Sport Medicine: Molecular hydrogen in sports medicine: new therapeutic perspectives

• Sport related injuries: Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries

• Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete (2020)

CANCER

• Hydrogen–water enhances 5-fluorouracil-induced inhibition of colon cancer

• Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice

• Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival (2018)

• Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression

• Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells

• Telomere Shortening in Cancer Cells by Electrolyzed-Reduced Water:

• Inhibitory Effect of Electrolyzed Reduced Water on Tumor Angiogenesis

• Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione.

• Electrolyzed Reduced Water Induces Differentiation in K-562 Human Leukemia Cells

• Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer (2019)

• Hydrogen inhibits endometrial cancer growth (2020)

• Hydrogen Gas in Cancer Treatment (2019)

  RADIOTHERAPY

• Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

• Hydrogen as a new class of radioprotective agent

• Molecular hydrogen and radiation protection

• The hypothesis of an effective safe and novel radioprotective agent

• The healing effect of hydrogen-rich water on acute radiation-induced skin injury (2019)

PH LEVEL EFFECT ON CANCER

• Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

• Microenvironmental pH is a key factor for exosome traffic in tumor cells.

• Acid-mediated tumor invasion: a multidisciplinary study.

• Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH

PARKINSONS

• Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats

• Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease

• Hydrogen therapy: from mechanism to cerebral diseases

• Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial

• Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease

• Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease

• A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease

• Parkinson's disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water, to protect the brain from oxidative stress.

• Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease (2019)

KIDNEY DISEASE

• Hydrogen: another gas with therapeutic potential

• Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation

• Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Lepr/NDmcr rat kidney

• Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats

• Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats

• The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

• The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice

STROKE

• Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats

• Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen

• Potential application of hydrogen in traumatic and surgical brain injury, stroke and neonatal hypoxia-ischemia

• The hydrogen highway to reperfusion therapy

OXIDATIVE STRESS

• Oxidative stress

• Oxidative Stress and Antioxidant Defense

• Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation

• Oxidative stress in human diseases

• Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

• Oxidative stress and psychological disorders

• A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress (2019)

• Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.

• Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies

• Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals

• The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved

• Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage

• Review and prospect of the biomedical effects of hydrogen

• Molecular hydrogen: a preventive and therapeutic medical gas for various diseases.

• Promising novel therapy with hydrogen gas for emergency and critical care medicine

• Does H2 Alter Mitochondrial Bioenergetics via GHS-R1α Activation?

• Fundamental Insight into the Methodology of Hydrogen Water in Biological Studies

• Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

• The Clinical Application of Hydrogen as a Medical Treatment

• Therapeutic Effects of Hydrogen on Different Diseases

• A hypothesis on chemical mechanism of the effect of hydrogen

• Reduced Water for Prevention of Diseases

• Electrolyzed–Reduced Water Scavenges Active Oxygen Species and Protects DNA from Oxidative Damage

• Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells (2017)

• Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption (2017)

ARTHRITIS

• Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study

• Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress

• Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases

• Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide

• Molecular hydrogen suppresses activated Wnt/β-catenin signaling

• Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study

• Alkaline Mineral Supplementation Decreases Pain in Rheumatoid Arthritis Patients

PSORIASIS

• Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis

• Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases

• Oxidant/Antioxidant Status in Patients with Psoriasis

• Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis

• Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis

HEART DISEASE

• Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

• Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart

• Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats

• Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice

• H2 Gas Improves Functional Outcome After Cardiac Arrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model

• Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats

• Hydrogen gas protects against serum and glucose deprivation‑induced myocardial injury in H9c2 cells through activation of the NF‑E2‑related factor 2/heme oxygenase 1 signaling pathway

• Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways

• Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation

• Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice

NEUROLOGICAL DISORDERS

• Molecular Hydrogen as a Neuroprotective Agent

• Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life (2018)

• Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration (2017)

• Hydrogen therapy: from mechanism to cerebral diseases

• Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells

• Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury

• Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration

• Effects of hydrogen-rich water on depressive-like behavior in mice

• Electrolyzed-reduced water mitigates amyloid beta toxicity via DAF-16 in C. elegans

• Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism

• Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress

• Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells

• Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia

• Molecular Hydrogen Reduces LPS-Induced Neuroinflammation and Promotes Recovery from Sickness Behaviour in Mice

• Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production

• Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

AUTISM

• Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production

• Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities

• Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism

DIABETES

• Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles

• Anti-Oxidative Water Improves Diabetes

• Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat mode

• Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle

• Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice

• Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

• Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus

• Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress

• Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice

• Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage

• Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice

• Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice

• Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes (2018)

• Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism

REFLUX DISEASE

• Potential benefits of pH 8.8 alkaline drinking water as an adjunct in the treatment of reflux disease

• Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen

• Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water

IBS

• Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study

• Long-Term Potable Effects of Alkalescent Mineral Water on Intestinal Microbiota Shift and Physical Conditioning (2020)

HEMODIALYSIS

• Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis

• Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water

• Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients

• Biological effects of electrolyzed water in hemodialysis

• Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients

• Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water

• A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis

• The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

GENE EXPRESSION AND MODULATION

• Preventive and Therapeutic Application of Molecular Hydrogen in Situations With Excessive Production of Free Radicals

• Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response

• Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages

• Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance

• Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision

• Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators

• Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism

• Molecular Hydrogen Reduces LPS-Induced Neuroinflammation and Promotes Recovery from Sickness Behaviour

• Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism

• Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles

OTHER WATER RESEARCH

• Health effects of long term consumption of water low in calcium, magnesium

• Seizures and delirium in a trekker: the consequences of excessive water drinking

• Drinking water and cardiovascular disease

• Drinking water hardness and chronic degenerative diseases.

• Drinking water hardness and chronic degenerative diseases. Part 2

• Components of drinking unfiltered water and risk of cognitive impairment in the elderly

• Association of very low birth weight with calcium levels in drinking water

• Calcium and magnesium in drinking water and risk of death from colon cancer

• Calcium, magnesium, and nitrate in drinking water and gastric cancer mortality

• Magnesium deficiency and sudden death

• Sudden cardiac death rate in an area characterized by high incidence of coronary artery disease and low hardness of drinking water

• Variation in the mineral content of commercially available bottled waters: implication for health and disease

• Influence of Increasing the Calcium and Magnesium Content of the Drinking Water on Performance and Bone and Plasma Minerals

• Pancreatic cancer mortality and total hardness levels in Taiwan's drinking water.

• Rectal cancer mortality and total hardness levels in Taiwan’s drinking water

• Calcium and magnesium in drinking water and the risk of death from breast cancer

• Magnesium in drinking water in relation to morbidity and mortality from acute myocardial infarction

• Changes in the mineral composition of food as a result of cooking in “hard“ and “soft“ waters

• Surveillance for Waterborne Disease Outbreaks United States

• Nutritional factors in relation to heavy metal toxicants

• Chemical qualities of water that contribute to human health in a positive way

• Typhoid fever from water desalinized using reverse osmosis

• Bacterial colonization of reverse-osmosis water filtration units

• Gastrointestinal health effects associated with the consumption of drinking water produced by point-of-use domestic reverse-osmosis filtration units

• Guidelines for Drinking-water Quality